Nestled in the heart of Ontario's wine country, this property is an unparalleled opportunity for a buyer looking to start a winery or for a winery looking to expand. With three road frontages totalling 5,932 feet of frontage & situated along King St this property has prime traffic exposure. The extraordinary 78-acre vineyard has some of the region's most sought-after soil composition, ideal for premium winemaking. Fully tile-drained & meticulously maintained, this expansive property is home to 10 distinct grape varietals, providing a diverse selection. A key feature of this property is the 2,400 sq ft barn, purpose-built for wine production. Equipped with all the essentials, this facility provides the infrastructure needed to create fine wine onsite, setting the stage for a full-service vineyard operation. In addition to the vineyard, this property offers a unique hospitality experience through the 3,340 sq ft Guesthouse. Originally a charming farmhouse, the guesthouse has been converted into a comfortable B&B retreat with two spacious three-bedroom suites & an additional two-bedroom suite. Perfect for visitors eager to immerse themselves in vineyard life, the guesthouse provides a welcoming stay for wine tourists or long-term guests seeking relaxation amidst scenic vineyard views. For those seeking a premier vineyard estate with production capabilities & guest accommodations, 4105 Tufford Rd offers a rare opportunity to acquire a prestigious, income-generating property in the heart of Niagara's wine region.